WebNational Center for Biotechnology Information WebApr 11, 2024 · STAT4 Signal transducer and activator of transcription 4 (STAT4) is a transcription factor with a key role in interferon signalling; STAT4 is activated and translocates to the nucleus after...

Distinct Roles for the NF-κB RelA Subunit during Antiviral Innate ...

WebThe innate immune system includes: Physical Barriers such as skin, the gastrointestinal tract, the respiratory tract, the nasopharynx, cilia, eyelashes and other body hair. Defense Mechanisms such as secretions, mucous, bile, gastric acid, saliva, tears, and sweat. General Immune Responses Webimmune responses characterized by humoral and cell-medi-ated responses which protect against future infection (42). Many pathogenic bacterial species possess the ability to modulate the innate immune response to evade host defenses and promote colonization, including several that block the activation of the NF-B pathway (7, 31, 32, 35, 36). We ... i have stood on the shoulders of giants quote

Innate and adaptive immune responses (SAB target list)

WebIL-12 plays a central role in the regulation of cellular immune responses, mainly as a result of its ability to induce the production of IFN- by effector cells of the innate and adaptive immune systems [1]. Previous studies have indicated that although IL-12 exerts effects that are independent of IFN- , WebNov 26, 2024 · The cytokines that activate STAT4 mainly include type I IFN, IL-12, and IL-23. 111,112 In mice and humans, STAT4 plays an essential role in the differentiation and development of Th1 cells and ... WebFeb 26, 2010 · STAT4 homodimers translocate to the nucleus and promote IFN-γ gene transcription. T-bet is another transcription factor that plays a role in Th1 development and IFN-γ production. The IL-12 and IFN-γ induce the activity and proliferation of MΦs, NK cells, and T cells, which also secrete IL-12. Modified from Ref. [ 34 ]. i have straight a\u0027s