WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. … WebOct 3, 2013 · In this work, 1H high resolution magic angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy was used to characterize the variations in the metabolome (small metabolites and mobile lipids) of A549 human lung cells in response to exposure to the alkylating drug cisplatin. Multivariate analysis and signal integration of …
1 H NMR toxicometabolomics following cisplatin-induced …
WebSep 9, 2024 · Response of Cisplatin Resistant Skov-3 Cells to [Pt ( O,O'-Acac) (γ-Acac) (DMS)] Treatment Revealed by a Metabolomic ¹H-NMR Study Response of Cisplatin Resistant Skov-3 Cells to [Pt ( O,O' -Acac) (γ-Acac) (DMS)] Treatment Revealed by a Metabolomic ¹H-NMR Study 2024 Sep 9;23 (9):2301. doi: 10.3390/molecules23092301. … WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... kinsley group inc
Geometries and NMR properties of cisplatin and ... - ScienceDirect
WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebSep 18, 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class of cytotoxic medications. This activity reviews the indications, action, and … WebAug 9, 2024 · A systematic and comparative 1H NMR metabolomics study to analyze the responses of A2780 human ovarian cancer cells to the main clinically established Pt drugs, i.e., cisplatin, carboplatin and oxaliplatin. Pt-Based drugs play a very important role in current cancer treatments; yet, their cellular and mechanistic aspects are not fully … kinsley grace imginn