WebApr 13, 2024 · PTHrP receptor 1 (PTH1R) is a receptor for PTH-related peptide (PTHrP). Parathyroid hormone (PTH) is a hormone that stimulates bone resorption and regulates …
Articular Chondrocytes Express the Receptor for …
WebAug 9, 2015 · Chondrocyte death and matrix loss may form a vicious cycle, with the progression of one aggravating the other, and the literature reveals that there is a definite correlation between the degree of cartilage damage and chondrocyte apoptosis. ... (TRAIL) receptors, members of tumor necrosis factor (TNF) receptor superfamily, are highly ... WebApr 4, 2024 · Results: Seven molecularly defined chondrocytes clusters (homeostatic chondrocytes, hypertrophic chondrocyte (HTC), pre-HTC, regulatory chondrocytes, fibro-chondrocytes (FC), pre-FC, and reparative chondrocyte) with different compositions were identified in the damaged cartilage. manifest season 4 plot
Spatially multicellular variability of intervertebral disc degeneration ...
WebJan 15, 2024 · SDF-1α, the most common isoform of stromal cell-derived factor 1, has shown vital effects in regulating chondrocyte proliferation, maturation, and chondrogenesis. Autophagy is a highly conserved biological process to help chondrocytes survive in harsh environments. However, the effect of SDF-1α on chondrocyte autophagy is still … WebAug 28, 2024 · Osteoclast-associated receptor blockade prevents articular cartilage destruction via chondrocyte apoptosis regulation Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most common form of age-related degenerative whole-joint disease. No disease-modifying treatments for OA are currently … WebFeb 14, 2024 · Mechanistically, GPR4 suppressed chondrocyte differentiation and upregulated cartilage homeostasis through NF-κB/MAPK signaling activation by regulating CXCR7/CXCL12 expression. Together, our results take the lead to illustrate that proton-activated GPCR acts as a key regulator for OA pathogenesis in vivo, and support that … manifest season 4 return date